Diplacon

Diplacone (DP) is a geranylated flavanone. Diplacone can be isolated from the unripe fruits of Paulownia tomentosa. Diplacone has anti-inflammatory, antiradical, cytoprotective, antibacterial and anticancer activities. Diplacone induces ferroptosis-mediated cell death by increasing mitochondrial Ca2+ Influx, ROS production and mitochondrial permeability transition. Diplacone significantly inhibits AChE and BChE activity with IC50s of 7.2 μM and 1.4 μM for hAChE and BChE, respectively. Diplacone can be used for chronic inflammatory diseases like inflammatory bowel diseases (IBD), cancers like lung cancer and Alzheimer’s disease research[1][2][3].

73676-38-7

Nymphaeol A; Propolin C

12352100

Calcium Channel; Cholinesterase (ChE) ; COX; Epigenetic Reader Domain; Ferroptosis; Reactive Oxygen Species (ROS)

Apoptosis; Epigenetics; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Cancer; Infection; Inflammation/Immunology; Neurological Disease

OC1=C2C(O[C@H](C3=CC(O)=C(C=C3)O)CC2=O)=CC(O)=C1C/C=C(C)/CC/C=C(C)\C

C25H28O6

424.49

[1]Vochyánová Z, et al. Diplacone and mimulone ameliorate dextran sulfate sodium-induced colitis in rats. Fitoterapia. 2015 Mar;101:201-7. |[2]Kang MJ, et al. Diplacone Isolated from Paulownia tomentosa Mature Fruit Induces Ferroptosis-Mediated Cell Death through Mitochondrial Ca2+ Influx and Mitochondrial Permeability Transition. Int J Mol Sci. 2023 Apr 11;24 (8) :7057.|[3]Cho JK, et al. Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits. Bioorg Med Chem. 2012 Apr 15;20 (8) :2595-602. doi: 10.1016/j.bmc.2012.02.044. Epub 2012 Mar 8. Erratum in: Bioorg Med Chem. 2012 Aug 1;20 (15) :4882.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N16129/

Natural Products

No Development Reported

AChE; BChE; COX-2