Diquat-d8 (dibromide)

Diquat-d8 dibromide is a deuterium labeled Diquat dibromide. Diquat dibromide is a comprehensive herbicide. Diquat dibromide increases the production of ROS and triggers mitochondrial Autophagy. Diquat dibromide generates free radicals such as superoxide anions through redox cycles, which induce oxidative stress. Diquat dibromide is cytotoxic, reproductive, and neurotoxic. Diquat dibromide is used in cotton, soybean, and other crops to combat noxious weeds[1][2][3][4][5][6][7][8].

12352005

Autophagy; Herbicide; Isotope-Labeled Compounds; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)

Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Metabolism-sugar/lipid metabolism

Endocrinology; Neurological Disease

[2H]C1=[N+]2C(C3=[N+](C([2H])=C(C([2H])=C3[2H])[2H])CC2)=C(C([2H])=C1[2H])[2H].[Br-].[Br-]

C12H4D8Br2N2

352.09

[1]Moreland D E. Mechanisms of action of herbicides. 1980.|[2]Cao S, et al. Diquat-induced oxidative stress increases intestinal permeability, impairs mitochondrial function, and triggers mitophagy in piglets. J Anim Sci. 2018 May 4;96 (5) :1795-1805.|[3]Singh P, et al. Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration. Parkinsons Dis. 2017;2017:2643587. |[4]Tomášek O, et al. Opposing effects of oxidative challenge and carotenoids on antioxidant status and condition-dependent sexual signalling. Sci Rep. 2016 Mar 22;6:23546. |[5]Nisar R, et al. Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria. Arch Toxicol. 2015 Oct;89 (10) :1811-25.|[6]Zhang JQ, et al. Chronic Exposure to Diquat Causes Reproductive Toxicity in Female Mice. PLoS One. 2016 Jan 19;11 (1) :e0147075. |[7]Karuppagounder SS, et al. Investigate the chronic neurotoxic effects of diquat. Neurochem Res. 2012 May;37 (5) :1102-11.|[8]Acar A. In vivo toxicological assessment of diquat dibromide: cytotoxic, genotoxic, and biochemical approach. Environ Sci Pollut Res Int. 2021;28 (34) :47550-47561.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W758421/

Isotope-Labeled Compounds

No Development Reported