DIS3L2 Antilichaam

The exosome is involved in a multitude of cellular RNA processing and degradation events (1) . DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species (2) . DIS3L2 is a paralog of DIS3, but unlike DIS3 is located in the cytoplasm (3) . DIS3L2 defines a novel eukaryotic RNA degradation pathway and preferentially targets uridylated RNA (4) . DIS3L2 mutations have also been associated with sporadic Wilms tumors (3) .

129563

Q8IYB7

NP_689596

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

DIS3L2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1282 - 3T3 (NIH) Cell Lysate

1 mg/mL

DIS3L2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DIS3L2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

DIS3L2 antibody is human, mouse and rat reactive. At least three isoforms of DIS3L2 are known to exist; this antibody will only detect the longest isoform. DIS3L2 is predicted to not cross-react with DIS3 or DIS3L.

DIS3L2

DIS3 like 3'-5' exoribonuclease 2

Homo sapiens

Chen CY, Gherzi R, Ong SE, et al. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell 2001; 107:451-64.

Brouwer R, Allmang C, Raijmakers R, et al. Three novel components of the human exosome. J. Biol. Chem. 2001; 276:6177-84.

Astuti D, Morris MR, Cooper WN, et al. Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility. Nat. Genet. 2012; 44:277-84.

Malecki M, Viegas SC, Carneiro T, et al. The exonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway. EMBO J. 2013; 32:1842-54.

DIS3 like 3'-5' exoribonuclease 2, FAM6A, PRLMNS

ELISA, WB

134288890

Liquid