Disorazol A

Disorazol A1 is an tubulin inhibitor with antifungal activity. Disorazol A1 functions by inhibiting tubulin polymerization, interfering with microtubule formation, blocking mitosis, thus arresting the cell cycle at the G2/M phase and inducing apoptosis. Disorazol A1 also exhibits an inhibitory effect against L929 mouse fibroblasts with an IC50 value of 3 pM. Disorazol A1 causes the accumulation of p53 protein in the cell nucleus. Disorazol A1 is promising for research of cancers[1].

158181-47-6

12352005

Apoptosis; Fungal; Microtubule/Tubulin; Mitosis

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Cancer-programmed cell death

Cancer

O=C(C1=COC(C[C@@H](OC)C=CC=CC=CC[C@@H](C(C)(C)[C@@H](O)/C=C/C)OC2=O)=N1)O[C@H](C(C)(C)[C@@H](O)/C=C/C)CC=C[C@@]3([H])O[C@@]3([H])C=CC=CC4=NC2=CO4

C43H54N2O10

758.90

[1]Elnakady YA, et al. Disorazol A1, a highly effective antimitotic agent acting on tubulin polymerization and inducing apoptosis in mammalian cells. Biochem Pharmacol. 2004 Mar 1;67 (5) :927-35.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N14734/

Natural Products

No Development Reported