DKK1 (NM 012242) Humaan Recombinant eiwit

This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]

Purified recombinant protein of Human dickkopf homolog 1 (Xenopus laevis) (DKK1), Thr32-End, with N-terminal His tag, expressed in E. coli, 50ug

DKK-1; SK

22943

O94907, I1W660

NM_012242

10q21.1

E. coli

N-His

Wnt signaling pathway

Wnt signaling pathway

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

50mM Tris, 8M Urea, pH8.0.

Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - Wnt Signaling pathway

25.8 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

DKK1

Human

NP_036374

https://www.ncbi.nlm.nih.gov/gene/22943

https://www.uniprot.org/uniprot/O94907

https://www.ncbi.nlm.nih.gov/nuccore/NM_012242

https://www.ncbi.nlm.nih.gov/nuccore/NP_036374