DLK1 Antilichaam

DLK1 Antibody: The Delta-like 1 homolog (DLK1) is a transmembrane protein containing six epidermal growth factor repeats. It is involved in the differentiation of several cell types, including adipocytes and is also thought to be a tumor suppressor. The DLK1 gene is one of several imprinted genes located in a region on chromosome 14q32; certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14) . DLK1 is expressed from the paternal allele; a polymorphism within this gene has been associated with child and adolescent obesity.

8788

P80370

NP_003827

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

DLK1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1211 - HepG2 Cell Lysate

1 mg/mL

DLK1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DLK1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

42 kDa

IgG

At least four isoforms of DLK1 are known to exist.

DLK1

Cat. No. 17-011 - Hep G2 Cell Slide

Delta-like 1 homolog (Drosophila)

Homo sapiens

Smas CM and Sul HS. Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 1993; 73:725-34.

Sul HS. Mini-review: Pref-1: role in adipogenesis and mesenchymal cell fate. Mol. Endocrinol. 2009; 23:1717-25.

Kawakami T, Chano T, Minami K, et al. Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma. Hum. Mol. Genet. 2006; 15:821-30.

Wermter AK, Scherag A, Meyre D, et al. Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdomainance in human. Eur. J. Hum. Genet. 2008; 16:1126-34.

DLK1 Antibody: DLK, Protein delta homolog 1, pG2, DLK-1

ELISA, WB, ICC, IF

74136023

Liquid