DMAP1 Antilichaam - C-terminalgebied : HRP (ARP39381_T100-HRP)

DNA methyltransferase 1 associated protein 1

EAF2, SWC4, MEAF2, DNMAP1, DNMTAP1

55929

Q9NPF5

NP_061973

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the C terminal region of human DMAP1

DMAP1 is a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.

SOX2; UBC; RNF2; HECW2; RUVBL2; SRCAP; CFDP1; RUVBL1; DENR; VPS72; TOMM34; TSG101; H2AFZ; DAXX; SMARCAD1; SUMO2; EPC1; ACTL6A; ACTA1; PPP2R2D; ING3; MORF4L1; BRD8; KAT5; TRRAP; YEATS4; EP400; EPC2; MYC; MAX; ACTG1; ACTB; MRGBP; MORF4L2; MNAT1; HDAC1; tat

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

53kDa

Oh, J.H., et al., (2005) Mamm. Genome 16 (12), 942-954

Wet Ice

467

DMAP1

DMAP1

Rabbit

DNA methyltransferase 1-associated protein 1

NM_019100

PGPASAEPAVTEPGLGPDPKDTIIDVVGAPLTPNSRKRRESASSSSSVKK