DMPX

DMPX (3,7-Dimethyl-1-propargylxanthine) is a BBB-penetrable caffeine analogue. DMPX is A2 selective adenosine receptor (AR) antagonist that strongly and selectively blocks hypothermia and behavioral inhibition induced by A2 adenosine receptor agonists such as NECA. DMPX can be used in the study of Parkinson's disease and other diseases[1][2].

14114-46-6

3,7-Dimethyl-1-propargylxanthine

12352005

H315, H319, H335

Adenosine Receptor

GPCR/G Protein

Neuroscience-Neurodegeneration

Neurological Disease

10mM

99.66

DMSO : 40 mg/mL (ultrasonic)

O=C1C2=C(N(C)C(N1CC#C)=O)N=CN2C

C10H10N4O2

218.21

H315, H319, H335

[1]Müller CE, et al. Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists. J Med Chem. 1997 Dec 19;40 (26) :4396-405.|[2]Seale TW, et al. 3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs. Life Sci. 1988;43 (21) :1671-84.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-W004425/DMPX-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported