DNA Ligase IV Polyklonale Antilichaam, PerCP-Cy5,5 Vervoeging

Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V (D) J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

LIG4S; DNA ligase 4; DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4; LIG4

3981

P49917

Human

51-150/911

DNA Ligase IV

PerCP-Cy5.5

KLH conjugated synthetic peptide derived from human DNA Ligase IV

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

482nm/694nm

1µg/µl

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

3981

Mouse, Rat, Dog, Cow, Sheep, Horse, Chicken, Rabbit