DNA PKcs (Ab 2609) Antilichaam

The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK) . The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties

5591

P78527

NP_001075109.1

Human

DNA PKcs (Ab-2609) antibody was raised against a peptide sequence around aa.2607~2611 (V-E-T-Q-A) derived from Human DNA-PK.

Unconjugated

Primary Antibodies

Cell Cycle

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

450 kDa

This antibody detects endogenous level of total DNA PKcs protein.

Western Blot: 1:500~1:1000

PRKDC

Protein kinase, DNA-activated, catalytic polypeptide

Homo sapiens

Chan DW, et al. (2002) Genes Dev. Sep 15; 16 (18) : 2333-2338Ding Q, et al. (2003) Mol Cell Biol. Aug; 23 (16) : 5836-5848Douglas P, et al. (2002) Biochem J. Nov 15; 368 (Pt 1) : 243-251

HYRC, p350, DNAPK, DNPK1, HYRC1, XRCC7, DNA-PKcs, EPLG5, HTKL, LERK5, PRKD, PRKDC, P460

WB

126032350

Liquid