DNAJC13 Antilichaam

DNAJC13, also known as receptor-mediated endocytosis 8 (RME8), is the human homolog to a DnaJ domain-containing protein originally identified in a screen for endocytic defects in C. elegans (1) . It is thought to be a co-chaperone of Hsc70 which regulates protein conformation at membrane sites and plays a role in intracellular trafficking, co-localizing with markers of the endosomal system. Recent experiments have indicated that the DNAJC13 protein is involved in membrane trafficking through early endosomes but not through degradative organelles (2) . DNAJC13 has been also been shown to regulate the intracellular trafficking of the epidermal growth factor receptor (3) .

23317

O75165

NP_056083

Human, Mouse

Unconjugated

Primary Antibodies

Homeostasis

DNAJC13 antibody is affinity chromatography purified via peptide column.

Cat. No. 1411 - Mouse Colon Tissue Lysate

1 mg/mL

DNAJC13 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DNAJC13 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

DNAJC13 antibody is human and mouse reactive. At least two siforms of DNAJC13 are known to exist; this antibody will detect both isoforms. DNAJC13 antibody is predicted to not cross-react with other DNAJC family members.

DNAJC13

Cat. No. 10-501 - Human Heart Tissue Slide

Cat. No. 1212 - 3T3 Cell Lysate

DnaJ (Hsp40) homolog, subfamily C, member 13

Homo sapiens

Girard M, Poupon V, Blondeau F, et al. The DnaJ-domain protein RME-8 functions in endosomal trafficking. J. Biol. Chem. 2005; 280:40135-43.

Fujibayashi A, Taguchi T, Misaki R, et al. Human RME-8 is involved in membrane trafficking through early endosomes. Cell Struct. Funct. 2008; 33:35-50.

Girard M and McPherson PS. RME-8 regulates trafficking of the epidermal growth factor receptor. FEBS Lett. 2008; 582:961-6.

DNAJ homolog subfamily C member 13, receptor-mediated endocytosis 8, RME8

ELISA, WB, IHC-P

112421122

Liquid