DNM1 Antilichaam - middengebied: Biotine (ARP51787 P050-Biotine)

Dynamin 1

DNM, DEE31, EIEE31

1759

P39053

NP_004399

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human DNM1

DNM1 is a member of the dynamin subfamily of GTP-binding proteins. The protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.

BIN1; SLA1; UBC; GRB2; AMPH; NCL; FANCD2; IRF2BPL; TBC1D2; NPM3; SNRPA1; SNX9; Fcho2; IQCB1; NCK2; NCK1; Asap1; SH3BP4; DNM1; PTK2B; PIAS1; SUMO1; UBE2I; SRC; ITSN1; SH3GL2; DYRK1A; CDK5; ARRB1; Ap2a1; SH3KBP1; DNM2; ADAM2; UBASH3A; KIAA1377; GRIN1; MED31

Biotin

Polyclonal Antibody

IHC, WB

Affinity Purified

0.5 mg/ml

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 86%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 86%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

95kDa

Chugh, J., (2007) Biochemistry 46 (42), 11819-11832

Wet Ice

851

DNM1

DNM1

Rabbit

Dynamin-1

NM_004408

PPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGPAPGPPPA