DNM1L Antilichaam

The Dynamin-1-like protein (DNM1L) is a member of the dynamin superfamily of GTPases (1) . DNM1L mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis (2) . Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF) (3) .

10059

O00429

NP_036192

Human, Mouse

Unconjugated

Primary Antibodies

Apoptosis

DNM1L antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (100%), Bovine: (100%)

DNM1L antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DNM1L antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

DNM1L antibody is human and mouse reactive. At least four isoforms of DNM1L are known to exist; this antibody will detect the two longest isoforms.

DNM1L

Cat. No. 17-001 - HeLa Cell Slide

Dynamin 1-like

Homo sapiens

Shin HW, Shinotsuka C, Torii S, et al. Identification and subcellular localization of a novel mammalian dynamin-related protein homologous to yeast Vps1p and Dnm1p. J. Biochem. 1997; 122:525-30.

Frank S, Gaume B, Bergmann-Leitner ES, et al. The role of dynamin-related protein1, a mediator of mitochondrial fission, in apoptosis. Dev. Cell 2001; 1:515-25.

Reddy PH, Reddy TP, Manczak M, et al. Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases. Brain Res. Rev. 2011; 67:103-18.

DNM1L Antibody: DLP1, DRP1, DVLP, EMPF, DYMPLE, HDYNIV, DLP1, Dynamin-1-like protein, Dynamin family member proline-rich carboxyl-terminal domain less

ELISA, WB, ICC, IF

171460914

Liquid