DNMT1 Antilichaam

This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.

1786

P26358

Human, Mouse, Rat

Recombinant protein of human DNMT1.

Unconjugated

Primary Antibodies

Other

Affinity purification

293T

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 200kDa

IgG

DNMT1

HeLa

Jurkat

SW480

NIH/3T3

C6

DNA (cytosine-5-) -methyltransferase 1

Homo sapiens

DNMT1, DNA (cytosine-5-) -methyltransferase 1, CXXC9, DNMT, FLJ16293, MCMT, MGC104992, DNA methyltransferase 1, AIM

WB, IHC, IF, IP

Liquid