DOC8 Antilichaam

The Dedicator of cytokinesis protein 8 (DOCK8) is a member of the DOCK180 family of guanine nucleotide exchange factors (1) . DOCK8 plays an essential role in humoral immune responses and is important in the proper formation of the B cell immunological synapse (reviewed in 2) . Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome (3) .

81704

Q8NF50

NP_982272

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Immunology

DOCK8 antibody is affinity chromatography purified via peptide column.

Cat. No. 1287 - EL4 Cell Lysate

1 mg/mL

DOCK8 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DOCK8 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

DOCK8 antibody is human, mouse and rat reactive. Multiple isoforms of DOCK8 are known to exist.

DOCK8

Cat. No. 10-901 - Human Spleen Tissue Slide

Dedicator of cytokinesis 8

Homo sapiens

Ruusala A and Aspenstrom P. Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology. FEBS Lett. 2004; 572:159-66.

Randall KL, Lambe T, Goodnow CC, et al. The essential role of DOCK8 in humoral immunity. Dis. Markers 2010; 29:141-50.

Engelhardt KR, McGhee S, Sinkler S, et al. Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal recessive form of hyper-IgE syndrome. J. Allergy Clin. Immunol. 2009; 124:1289-302.

DOCK8 Antibody: MRD2, ZIR8, HEL-205, Dedicator of cytokinesis protein 8

ELISA, WB, IHC-P

238231392

Liquid