Docarpamine

Docarpamine is an orally active dopamine prodrug that can be hydroxylated in the small intestine and liver to form active dopamine. Docarpamine mainly activates D1-like receptors in peripheral blood vessels to lower blood pressure and heart rate in a state of spontaneous hypertension. Docarpamine exerts a pressor and tachycardic effect by activating D1-like receptors, vasopressin V1 receptors, and α-adrenergic receptors in normal blood pressure conditions. Docarpamine can be used for research on renal vascular dilation and diuresis[1][2].

74639-40-0

12352005

Adrenergic Receptor; Dopamine Receptor; Vasopressin Receptor

GPCR/G Protein; Neuronal Signaling

Neuroscience-Neuromodulation

Cardiovascular Disease

CCOC(OC1=C(C=C(C=C1)CCNC([C@@H](NC(C)=O)CCSC)=O)OC(OCC)=O)=O

C21H30N2O8S

470.54

[1]Sanada H, et al. The effect of docarpamine, a dopamine pro-drug, on blood pressure and catecholamine levels in spontaneously hypertensive rats. Clin Exp Hypertens. 2000 May;22 (4) :419-29.|[2]Tsunoda T, et al. Treatment for ovarian hyperstimulation syndrome using an oral dopamine prodrug, docarpamine. Gynecol Endocrinol. 2003 Aug;17 (4) :281-6.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W752502/

Reference compound1

No Development Reported

D1 Receptor; α adrenergic receptor