DOK1 Antilichaam

DOK1 Antibody: Signals from most growth factors and cytokines are transduced by receptor tyrosine kinases or non-receptor tyrosine kinases. Activated tyrosine kinases phosphorylate their substrates, which mediate the cellular response to extracellular stimuli. A long-sought major substrate termed p62dok (downstream of tyrosine kinase) for many tyrosine kinases including c-kit, v-abl, v-Fps, v-Src, v-Fms, and activated EGF, PDGF, IGF, VEGF and insulin receptors was identified recently from human and mouse by several laboratories. Upon phosphorylation, p62dok forms a complex with the ras GTPase-activating protein (RasGAP) . p62dok represents a new family with very recently identified p56dok.

1796

Q99704

Q99704.1

Human

Unconjugated

Primary Antibodies

Signal Transduction, Cancer

DOK1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1205 - Jurkat Cell Lysate

1 mg/ml

DOK1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DOK1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

62 kDa

IgG

DOK1

Cat. No. 1208 - THP-1 Cell Lysate

Cat. No. 1204 - K562 Cell Lysate

Cat. No. 17-004 - K-562 Cell Slide

Docking protein 1

Homo sapiens

Carpino N, Wisniewski D, Strife A, Marshak D, Kobayashi R, Stillman B, Clarkson B p62 (dok) : a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell 1997;88:197-204.

Yamanashi Y, Baltimore D Identification of the Abl- and rasGAP-associated 62 KDa protein as a docking protein, Dok. Cell 1997;88:205-211.

Holland SJ, Gale NW, Gish GD, Roth RA, Songyang Z, Cantley LC, Henkemeyer M, Yancopoulos GD, Pawson T. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. EMBO J 1997;16:3877-3888.

Di Cristofano A, Carpino N, Dunant N, Friedland G, Kobayashi R, Strife A, Wisniewski D, Clarkson B, Pandolfi PP, Resh MD. Molecular cloning and characterization of p56 (dok-2) defines a new family of RasGAP-binding proteins. J Biol Chem 1998;273:4827-4830.

DOK1 Antibody: Docking protein 1, Downstream of tyrosine kinase 1, P62 (dok), pp62

ELISA, WB, ICC, IF

17366642

Liquid