Domperidon-13C6
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Domperidone-13C6 (R33812-13C6) is 13C labeled Domperidone. Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1].
R33812-13C6
12352005
Dopamine Receptor; Isotope-Labeled Compounds
GPCR/G Protein; Neuronal Signaling; Others
Neuroscience-Neuromodulation
Neurological Disease
O=C1NC2=CC(Cl)=CC=C2N1C3CCN(CCCN(C(NC)=O)C)CC3.[13CH]4=[13CH][13CH]=[13CH][13CH]=[13CH]4
C18 13C6H32ClN5O2
463.95
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Reddymasu SC, et al. Domperidone: review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol. 2007;102 (9) :2036-2045.|[3]Champion MC, et al. Domperidone, a new dopamine antagonist. CMAJ. 1986;135 (5) :457-461.|[4]Stoetzer C, et al. Cardiotoxic Antiemetics Metoclopramide and Domperidone Block Cardiac Voltage-Gated Na+ Channels. Anesth Analg. 2017 Jan. 124 (1) :52-60.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-B0411S2/
Isotope-Labeled Compounds
No Development Reported
Beschrijving
Domperidone-13C6 (R33812-13C6) is 13C labeled Domperidone. Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone ac
Specificaties
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