Dopamine D2 Receptor (DRD2) (NM 000795) Aanbevolen eiwit bij de mens

This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]

Purified recombinant protein of Human dopamine receptor D2 (DRD2), transcript variant 1, Ile214-Gln373, with N-terminal His tag, expressed in E. coli, 50ug

D2DR; D2R

1813

P14416, A0A024R3C5

NM_000795

11q23.2

E. coli

N-His

Gap junction, Neuroactive ligand-receptor interaction

Gap junction, Neuroactive ligand-receptor interaction

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

50mM Tris, 8M Urea, pH8.0.

Druggable Genome, GPCR, Transmembrane

18.3 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

DRD2

Human

NP_000786

https://www.ncbi.nlm.nih.gov/gene/1813

https://www.uniprot.org/uniprot/P14416

https://www.ncbi.nlm.nih.gov/nuccore/NM_000795

https://www.ncbi.nlm.nih.gov/nuccore/NP_000786