DOTA-FAPT

DOTA-FAPT is a novel targeting FAP tracer. DOTA-FAPT can be radiolabeled with gallium-68 and lutetium-177. DOTA-FAPT can be used for PET imaging studies of cancer-associated fibroblasts[1].

12352209

Radionuclide-Drug Conjugates (RDCs)

Antibody-drug Conjugate/ADC Related

Cancer

O=C(COCCOCCNC([C@H](CC(O)=O)NC([C@H](CC(O)=O)NC([C@@H](NC(CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(O)=O)=O)CCC(N[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)NC(C)=O)=O)=O)=O)=O)N3CCN(CCCOC4=CC=C(C5=C4)N=CC=C5C(NCC(N6CC(F)(C[C@]6(C#N)[H])F)=O)=O)CC3

C67H96F2N16O26

1579.57

[1]Huang J, et al. 68Ga/177Lu-Labeled Theranostic Pair for Targeting Fibroblast Activation Protein with Improved Tumor Uptake and Retention. J Med Chem. 2024 Oct 10;67 (19) :17785-17795.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11254/

Peptides

No Development Reported