DOTAGA-anhydride (GMP)

DOTAGA-anhydride (GMP) is DOTAGA-anhydride produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride has been successfully used for labeling antibodies (e.g., Trastuzumab (HY-P9907) ). DOTAGA-anhydride can be used for the synthesis of a bimodal tag for Single-photon emission computed tomography (SPECT) or PET/optical imaging[1].

1375475-53-8

12352005

Radionuclide-Drug Conjugates (RDCs)

Antibody-drug Conjugate/ADC Related

Cancer

O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(C(CCC(O2)=O)C2=O)CC1

C19H30N4O9

458.46

[1]Bernhard C, et al. DOTAGA-anhydride: a valuable building block for the preparation of DOTA-like chelating agents. Chemistry. 2012 Jun 18;18 (25) :7834-41.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W087187G/

GMP Small Molecules

No Development Reported

RDC Bifunctional Chelator