Doxercalciferol-d6

Doxercalciferol-d6 (1.alpha.-Hydroxyvitamin D2-d6) is deuterium labeled Doxercalciferol. Doxercalciferol is a Vitamin D2 analog, acts as an activator of Vitamin D receptor, and prevent renal disease.

1.alpha.-Hydroxyvitamin D2-d6

12352211

Isotope-Labeled Compounds; VD/VDR

Others; Vitamin D Related/Nuclear Receptor

Metabolism-sugar/lipid metabolism

Metabolic Disease; Cancer

C[C@@]12[C@](CC[C@]2([H])[C@H](C)/C=C/[C@H](C)C(C([2H])([2H])[2H])C([2H])([2H])[2H])([H])/C(CCC1)=C/C=C3C([C@H](C[C@@H](C\3)O)O)=C

C28H38D6O2

418.68

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Noonan W, et al. Differential effects of vitamin D receptor activators on aortic calcification and pulse wave velocity in uraemic rats. Nephrol Dial Transplant. 2008 Dec;23 (12) :3824-30.|[3]Wang XX, et al. Vitamin D receptor agonist doxercalciferol modulates dietary fat-induced renal disease and renal lipid metabolism. Am J Physiol Renal Physiol. 2011 Mar;300 (3) :F801-10.|[4]Wang Y, et al. Vitamin D receptor signaling in podocytes protects against diabetic nephropathy. J Am Soc Nephrol. 2012 Dec;23 (12) :1977-86.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-32348S1/

Isotope-Labeled Compounds

No Development Reported