DR1 Antilichaam

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.

1810

Q01658

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 1-176 of human DR1 (NP_001929.1) .

Unconjugated

Primary Antibodies

Transcription

Affinity purification

Mouse spleen

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 19kDa

IgG

DR1

Down-regulator of transcription 1, TBP-binding (negative cofactor 2)

Homo sapiens

DR1, NC2, NC2-BETA

WB, IHC, IF

Liquid