DR5 Antilichaam

DR5 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-κ B.

8795

O14763

AF012535

Human, Mouse, Rat

Unconjugated

Primary Antibodies

KO Validation (Figure 12) shows DR5 expression detected by anti-DR5 antibodies (2019) was disrupted in DR5 KO HCT116 cells. KO Validation2019 KD validation (Figure 13) : Anti-DR5 antibody (2019) specificity was further verified by DR5 specific knockdown. DR5 signal in MB231 cells transfected with DR5 siRNAs was disrupted in comparison with that in cells transfected with control siRNAs. KD validation2019 Regulated expression validation (Figure 12, 15) : DR5 expression detected by anit-DR5 antibodies (2019) was up-regulated by carfilzomib treatment and was down-regulated by treatment with two or more cytokines. Regulated expression validation2019

Apoptosis

DR5 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/ml

DR5 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DR5 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

Antibody has no cross reaction to DR4.

Human DR5 has 3 isoforms, including isoform L (440aa, 48kD), isoform S (411aa, 45kD) and isoform 3 (118aa, 13kD) . Mouse DR5 has 1 isoform (381aa, 42kD), and Rat DR5 also has 1 isoform (336aa, 37kD) . 2019 can detect two human isoforms and can also detect mouse and rat isoforms.

TNFRSF10B

Cat. No. 1204 - K562 Cell Lysate

Cat. No. 17-001 - HeLa Cell Slide

Cat. No. 1282 - 3T3/NIH Cell Lysate

Cat. No. 1285 - C2C12 Cell Lysate

Tumor necrosis factor receptor superfamily, member 10b

Homo sapiens

Pan et al. Science 1997;277:815-8.

Sheridan et al. Science 1997;277:818-21.

Walczak et al. EMBO J 1997;16:5386-97.

MacFarlane et al. J Biol Chem 1997;272:25417-20

26009898

18266105

27827395

11859410

19570774

17470478

21953056

20371690

21385927

23766363

23833311

23319802

21685476

18846110

20562908

18193086

18362888

27387452

30059709

24287696

DR5 Antibody: DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5, DR5, UNQ160/PRO186, Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, TRAIL receptor 2

ELISA, WB, IHC-P, IF

2338419

Liquid