DR6 Antilichaam

DR6 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κ B and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.

27242

O75509

AF068868

Human

Unconjugated

Primary Antibodies

Apoptosis

DR6 Antibody is DEAE purified.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/ml

Predicted species reactivity based on immunogen sequence: Rat: (73%), Mouse: (73%)

DR6 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DR6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

68 kDa

IgG

TNFRSF21

Cat. No. 1204 - K562 Cell Lysate

Tumor necrosis factor receptor superfamily, member 21

Homo sapiens

Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett 1998;431:351-6

DR6 Antibody: DR6, CD358, BM-018, DR6, UNQ437/PRO868, Tumor necrosis factor receptor superfamily member 21, Death receptor 6

ELISA, WB

3549262

Liquid