DR6 Antilichaam [Luke-1]

27242

O75509

Human

DR6 (monoclonal Luke-1) antibody was raised against recombinant human DR6; Fc (aa. 42-335) .

Luke-1

Unconjugated

Primary Antibodies

Apoptosis

DR6 (monoclonal Luke-1) antibody was purified to ≥95% in SDS-PAGE.

Batch dependent

PBS containing 0.02% sodium azide

None

Blue Ice

DR6 antibody can be stored at 4˚ C, stable for one year.

IgG2a

DR6 antibody can be used to recognize human DR6 by Flow Cytometry. Method: Cells (5x105) were incubated on ice for 30 min in 50 μ l FACS buffer (PBS, 5% FCS, 0.02% azide) containing 1 μ g/mL of anti-DR6 MAb (Luke-1) . After washing in FACS buffer, R-PE-conjugated antibody to rat IgG was added. Cells were incubated on ice for 30 min, washed and analyzed by flow cytometry. Method: 3 HEK 293T cells (5 x 105) were mock transfected (thin line) or transfected with an expression plasmid enabling surface expression of mDR6 (thick line) . Cells were incubated on ice for 30 min in 50 μ l FACS buffer (PBS, 5% Fetal calf serum, 0.02% azide) containing 1 μ g/mL of Luke-1 antibody. After washing in FACS buffer, PE-conjugated antibody to rat IgG was added. Cells were incubated on ice for 30 min, washed and then analyzed by flow cytometry.

Tumor necrosis factor receptor superfamily, member 21

Homo sapiens

Identification and functional characterization of DR6, a novel death domain-containing TNF receptor : G. Pan, et al.; FEBS Lett 431, 351 (1998) .

Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice : H. Zhao, et al.; J. Exp. Med. 194, 1441 (2001) .

Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice:J. Liu, et al.; Immunity 15, 23 (2001) .

Flow

Liquid