DRGX Antilichaam

DRGX Antibody: DRGX, also known as DRG11 or PRRXL1, is a paired homeodomain transcription factor, and was initially cloned from a differential hybridization screen aimed at identifying dorsal root ganglia (DRG) -specific genes. DRGX is a key regulator of the differentiation of the spinal cord neuronal circuit dedicated to the processing of nociceptive information. DRGX is also important for the formation of the whisker-related somatosensory maps in the principal sensory nucleus of the trigeminal nerve, thalamus and somatosensory cortex.

644168

A6NNA5

NP_001073989

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

DRGX Antibody is affinity chromatography purified via peptide column.

Cat. No. 1464 - Rat Liver Tissue Lysate

1 mg/mL

DRGX Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DRGX antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgY

At least two are known to exist; DRGX antibody is predicted to not cross-react with other Homeodomain proteins.

DRGX

Dorsal root ganglia homeobox

Homo sapiens

Saito T, Greenwood A, Sun Q et al. Identification by differential RT-PCR of a novel paired homeodomain protein specifically expressed in sensory neurons and a subset of their CNS targets. Mol. Cell. Neurosci. 1995; 6:280-92.

Chen ZF, Rebelo S, White F et al. The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron 2001; 31:59-73.

Ding YQ, Yin J, Xu HM, et al. Formation of whisker-related principal sensory nucleus-based lemniscal pathway requires a paired homeodomain transcription factor, Drg11. J. Neurosci. 2003; 23:7246-54

Rebelo S, Lopes C, Lima D, et al. Expression of a Prrxl1 alternative splice variant during the development of the mouse nociceptive system. Int. J. Dev. Biol. 2009; 53:1089-95.

DRGX Antibody: DRG11, PRRXL1, Dorsal root ganglia homeobox protein, Paired-related homeobox protein-like 1

ELISA, WB, IF

122937484

Liquid