DRP1 (fosfo Ser637) Antilichaam

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation.

10059

O00429

NP_036192.2

Human, Mouse, Rat

DRP1 (phospho Ser637) antibody was raised against a peptide sequence around phosphorylation site of Serine 637 (K-L-S (p) -A-R) derived from Human DRP1.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

82 kDa

IgG

The antibody detects endogenous levels of DRP1 only when phosphorylated at serine 637.

Western Blot: 1:500~1:1000

DNM1L

Dynamin 1-like

Homo sapiens

Shin H.-W., J. Biochem. 122:525-530 (1997) .

Hong Y.-R., Biochem. Biophys. Res. Commun. 249:697-703 (1998) .

Imoto M., J. Cell Sci. 111:1341-1349 (1998) .

DLP1, DNM1L, DRP1, DVLP, Dymple

WB

171460914

Liquid