DSM1465

DSM1465 (Compound 82) is a potent, selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM, inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM. DSM1465 shows potent in vivo activity in the humanized P. falciparum mouse model[1].

12352005

Dihydroorotate Dehydrogenase; Parasite

Anti-infection; Metabolic Enzyme/Protease

Infection

O=C1C2=NN(C)C([C@](O)(C3=CC(Cl)=C(C(F)(F)F)N=C3)C(F)(F)F)=C2N=CN1C4CC4

C17H12ClF6N5O2

467.75

[1]Nie Z, et al. Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention. J Med Chem. 2025 Jan 9;68 (1) :590-637.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-170780/

Reference compound1

No Development Reported