DT-2 (acetaat)

DT-2 is a potent and selective inhibitor of the cGMP-dependent protein kinase (PKG) . DT-2 inhibits PKG catalyzed phosphorylation (Ki: 12.5 nM) [1].

12352209

PKG

Stem Cell/Wnt

Cancer-Kinase/protease

Cancer

98.64

O=C(N1[C@@H](CCC1)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CC2=CN=CN2)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]3N(CCC3)C([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC(CNC([C@@H](N)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C

C154H287N53O55

3761.25

[1]Pinkse MWH, et al. Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry. J Biol Chem. 2009 Jun 12;284 (24) :16354-16368.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P2692B/DT-2-acetate-SDS-MedChemExpress.pdf

Peptides

No Development Reported