
DTX3L Polyklonale Antilichaam, Cy5 Vervoeging
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) . Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
BBAP; E3 ubiquitin-protein ligase DTX3L; B-lymphoma- and BAL-associated protein; Protein deltex-3-like; Rhysin-2; Rhysin2; DTX3L
151636
Q8TDB6
Cytoplasm, Nucleus
• Rabbit
Human, Mouse, Rat
651-740/740
DTX3L
• Polyclonal
• IgG
Cy5
KLH conjugated synthetic peptide derived from human DTX3L
FCM, IF (IHC-P), IF (IHC-F), IF (ICC)
Purified by Protein A.
625,650nm/670nm
1µg/µl
FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Unmodified
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
151636
Rabbit
Beschrijving
DTX3L Polyklonale Antilichaam, Cy5 Vervoeging Beschikbaar in 100 µL. Bestel eenvoudig online met snelle levering.
Specificaties
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