DTX4 Antilichaam

The Deltex 4 E3 ubiquitin ligase (DTX4) is a member of a protein family that is involved in Notch signaling and neurogenesis (1) . Recent studies have shown that DTX4 is also associated with the innate immune response (2) . Following the activation of type I interferon signaling, the Nod-like receptor protein 4 (NLRP4) recruits DTX4 for Lys48-linked polyubiquitination and degradation of the kinase TBK1 (NAK), thereby maintaining immune homeostasis during antiviral innate immunity (2) .

23220

Q9Y2E6

NP_055992

Human

Unconjugated

Primary Antibodies

Neuroscience, Innate Immunity

DTX4 antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

DTX4 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DTX4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

DTX4 antibody is human and mouse reactive. At least two isoforms of DTX4 are known to exist; this antibody will detect both isoforms. DTX4 antibody is predicted to not cross-react with other DTX protein family members.

DTX4

Cat. No. 10-901 - Human Spleen Tissue Slide

Deltex 4, E3 ubiquitin ligase

Homo sapiens

Kishi N, Tang Z, Maeda Y, et al. Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Int. J. Dev. Neurosci. 2001; 19:21-35.

Cui J, Li Y, Zhu L, et al. NLRP4 negatively regulated type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4. Nat. Immunol. 2012; 13:387-95.

Deltex 4 E3 ubiquitin ligase, RNF155

ELISA, WB, IHC-P, IF

148237498

Liquid