Dubermatinib
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Potent (IC50 = 27 nM) inhibitor of the TAM family kinase AXL.1 It displayed potent activity against the pancreatic tumor cell line PSN-1 (IC50 = 6 nM) . Dubermatinib also strongly inhibited the kinases Aurora A/B, JAK2, ABL1, and CHEK1. It induced apoptosis in chronic lymphocytic leukemia (CLL) cells and acted synergistically with BTK inhibitors against CLL cells.2 It inhibited neuroblastoma cell growth and enhanced sensitivity to conventional chemotherapy.3 Dubermatinib was also active in a drug-resistant acute myeloid leukemia model4 and reduced metastasis and therapy resistance in pancreatic cancer models5.
Unconjugated
White solid
-20°C
Beschrijving
Dubermatinib Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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