Duloxetine-d5 (oxalaat)

Duloxetine-d5 (oxalate) ((S) -Duloxetine-d5 (oxalate) ) is deuterium labeled Duloxetine. Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) [1][2].

1276197-53-5

(S) -Duloxetine-d5 (oxalate) ; LY248686-d5 (oxalate)

12352005

Isotope-Labeled Compounds; Serotonin Transporter

Neuronal Signaling; Others

Cancer-programmed cell death

Neurological Disease; Cancer

OC(C(O)=O)=O.[2H]C([2H])([2H])NC([2H])([2H])C[C@@H](C1=CC=CS1)OC2=CC=CC3=C2C=CC=C3

C20H16D5NO5S

392.48

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]De Berardis, D., et al., The effect of newer serotonin-noradrenalin antidepressants on cytokine production: a review of the current literature. Int J Immunopathol Pharmacol, 2010. 23 (2) : p. 417-22.|[3]Wang, S.Y., J. Calderon, and G. Kuo Wang, Block of neuronal Na+ channels by antidepressant duloxetine in a state-dependent manner. Anesthesiology, 2010. 113 (3) : p. 655-65.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0161S3/

Isotope-Labeled Compounds

No Development Reported