DUSP2 Antilichaam

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.

1844

Q05923

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 150-250 of human DUSP2 (NP_004409.1) .

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Cell Cycle, Signal Transduction

Affinity purification

293T

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 34kDa

IgG

WB: 1:500 - 1:2000

DUSP2

NIH/3T3

HeLa

MCF7

Dual specificity protein phosphatase 2

Homo sapiens

Dual specificity protein phosphatase 2, Dual specificity protein phosphatase PAC-1, DUSP2, PAC1

WB

Liquid