DUSP5 Antilichaam

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.

1847

Q16690

Human

Recombinant fusion protein containing a sequence corresponding to amino acids 315-384 of human DUSP5 (NP_004410.3) .

Unconjugated

Primary Antibodies

Signal Transduction

Affinity purification

Raji

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 42kDa

IgG

WB: 1:500 - 1:2000

DUSP5

Dual specificity phosphatase 5

Homo sapiens

DUSP, HVH3, dual specificity protein phosphatase 5, VH1-like phosphatase 3, dual specificity protein phosphatase hVH3, serine/threonine specific protein phosphatase

WB

Liquid