DUSP6 Antilichaam

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.

1848

Q16828

Human

A synthetic peptide of human DUSP6

Unconjugated

Primary Antibodies

Immunology, Neuroscience, Signal Transduction

Affinity purification

HeLa

Batch dependent

PBS with 0.02% sodium azide, pH7.3.

None

Blue Ice

Store at 4˚ C. Avoid freeze / thaw cycles.

Observed: 45kDa

IgG

DUSP6

Dual specificity phosphatase 6

Homo sapiens

DUSP6, dual specificity phosphatase 6, MKP3, PYST1, MAP kinase phosphatase 3, dual specificity protein phosphatase 6, dual specificity protein phosphatase PYST1, mitogen-activated protein kinase phosphatase 3, serine/threonine specific protein phosphatase

WB, IF

Liquid