DY-9760e

DY-9760e is a calmodulin (CaM) inhibitor. DY-9760e selectively inhibits the activity of various calmodulin-dependent enzymes by antagonizing the Ca²⁺/CaM complex, exhibiting the strongest inhibitory activity against nNOS, CaM kinase II, and calcineurin (Ki: 0.9, 1.4, and 2.0 μM, respectively) . DY-9760e inhibits excessive nitric oxide production and protein tyrosine nitration, as well as the activation of calpain and caspase-3. DY-9760e reduces infarct size, improves cardiac function, and inhibits oxidative stress and cell death. DY-9760e can be used in research on the treatment of myocardial infarction, cerebral ischemia, and other diseases[1].

179185-73-0

12352005

Calcineurin; Calmodulin; CaMK; Caspase; NO Synthase; Proteasome

Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Neuroscience-Neurodegeneration

Cardiovascular Disease

ClC1=CC=CC(N2CCN(CC2)CCC3=NN(CC4=CN=CN4)C5=C3C=C(OC)C(OC)=C5)=C1C.Cl.[7/2H2O].Cl

C26H31ClN6O2.2ClH.7/2H2O

630.50

[1]Fukunaga K, et al. DY-9760e, a novel calmodulin inhibitor, exhibits cardioprotective effects in the ischemic heart. Cardiovasc Drug Rev. 2006 Summer;24 (2) :88-100.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19230/

Reference compound1

No Development Reported

CaMK II; Caspase 3; nNOS