DYNLL1 Antilichaam

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.

8655

P63167

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 1-89 of human DYNLL1 (NP_003737.1) .

Unconjugated

Primary Antibodies

Apoptosis, Autophagy, Cancer, Cell Cycle, Neuroscience, Signal Transduction

Affinity purification

HepG2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 12kDa

IgG

DYNLL1

HeLa

A-549

293T

NIH/3T3

Rat spinal cord

Dynein, light chain, LC8-type 1

Homo sapiens

DYNLL1, DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, MGC126137, MGC126138, PIN, hdlc1

WB, IHC, IF

Liquid