DZ2002 (Standaard)

DZ2002 (Standard) is the analytical standard of DZ2002. This product is intended for research and analytical applications. DZ2002 is an orally active, reversible and low-cytotoxic type III SAHH inhibitor (Ki=17.9 nM), with good immunosuppressive activity. DZ2002 prevents the development of experimental dermal fibrosis by reversing the profibrotic phenotype of various cell types. DZ2002 can be used in studies of autoimmune diseases such as lupus syndrome and systemic sclerosis[1][2].

33231-14-0

12352100

Akt; Antibiotic; Bacterial; ERK; MEK; NF-κB; PI3K; Reference Standards; STAT

Anti-infection; JAK/STAT Signaling; MAPK/ERK Pathway; NF-κB; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Inflammation/Immunology

OC(C(OC)=O)CCN1C(N=CN=C2N)=C2N=C1

C10H13N5O3

251.25

[1]Wu QL, et al. Inhibition of S-adenosyl-L-homocysteine hydrolase induces immunosuppression. J Pharmacol Exp Ther. 2005 May;313 (2) :705-11. |[2]Zhang Z, et al. DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models. Arthritis Res Ther. 2019 Dec 16;21 (1) :290.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-18620R/

Reference Standards