E Cadherine (CD324) Antilichaam

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

999

P12830

NP_004351.1

Human, Mouse, Rat

E-Cadherin (CD324) antibody was raised against a peptide sequence around aa.864~868 (E-W-G-N-R) derived from Human E-Cadherin.

Unconjugated

Primary Antibodies

Stem Cell

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

135 kDa

This antibody detects endogenous level of total E-Cadherin protein.

Western Blot: 1:500~1:1000

CDH1

Cadherin 1, type 1, E-cadherin (epithelial)

Homo sapiens

Baki L. et. al (2001) Proc. Natl. Acad. Sci. U. S. A. 98:2381-2386Makagiansar I. T. et. al (2002) J. Biol. Chem. 277:16002-16010Agiostratidou G. (2006) J. Neurochem. 96:1182-1188

UVO, CDHE, ECAD, LCAM, Arc-1, CD324, CDH1, UVO

WB

4757960

Liquid