E16-uPA24

E16-uPA24 is a chimeric peptide targeting urokinase-type plasminogen activator receptor (uPAR) . E16-uPA24 modifies senescent cells surface with polyglutamic acid, promoting immune cell-mediated responses through glutamate recognition. E16-uPA24 induces immune clearance of senescent cells and restores tissue homeostasis by enhancing immune cells recruitment and directly coupling senescent cells and immune cells. E16-uPA24 can be used for tissue degeneration, chronic inflammatory disease and age-related tumorigenesis research[1].

12352209

Others

Others

Metabolism-protein/nucleotide metabolism

Cancer; Metabolic Disease; Inflammation/Immunology

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C198H304N56O80S4

4877.12

[1]Ming X, et al. A chimeric peptide promotes immune surveillance of senescent cells in injury, fibrosis, tumorigenesis and aging. Nat Aging. 2025 Jan;5 (1) :28-47.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11023/

Peptides

No Development Reported