E2A (fosfo Thr355) Antilichaam

E2A is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described.

6929

P15923

NP_003191.1

Human, Mouse, Rat

E2A (phospho Thr355) antibody was raised against a peptide sequence around phosphorylation site of threonine 355 (P-S-T (p) -P-V) derived from Human E2A .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

67 kDa

IgG

The antibody detects endogenous levels of E2A only when phosphorylated at threonine 355.

TCF3

Transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)

Homo sapiens

Kamps M.P., Cell 60:547-555 (1990) .

Nourse J., Cell 60:535-545 (1990) .

Grimwood J., Nature 428:529-535 (2004) .

E12, Tran, TCF3, TFE2, ITF1

IHC

27777636

Liquid