E2F1 Antilichaam

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

1869

Q01094

Human, Mouse, Rat

A synthetic peptide of human E2F1

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Cell Cycle, Signal Transduction, Transcription

Affinity purification

Mouse brain

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 70kDa

IgG

E2F1

Rat brain

Rat testis

E2F transcription factor 1

Homo sapiens

E2F1, E2F-1, RBBP3, RBP3, RBAP1

WB, IF

Liquid