E2F3 Antilichaam

The E2F transcription factor 3 (E2F3) is a member of a small family of transcription factors that function through binding of DP interaction partner proteins. E2F3 recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle (1) . Like the related E2F1 and E2F2, E2F3 is essential for cellular proliferation and progression through the cell cycle (2) . Altered copy number and activity of this gene have been observed in a number of human cancers (3) .

1871

O00716

NP_001940

Human, Mouse

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

E2F3 antibody is affinity chromatography purified via peptide column.

Cat. No. 1369 - Human Lymph node Tissue Lysate

1 mg/mL

E2F3 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

E2F3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

E2F3 antibody is human and mouse reactive. At least three isoforms of E2F3 are known to exist; this antibody will detect only the largest isoform. This antibody is predicted to not cross-react with other members of the E2F transcription factor family.

E2F3

Cat. No. 11-521 - Human Lymphoid Tissue Tissue Slide

E2F transcription factor 3

Homo sapiens

Lees JA, Saito M, Vidal M, et al. The retinoblastoma protein binds to a family of E2F transcription factors. Mol. Cell. Biol. 1993; 13:7813-25.

Wu L, Timmers C, Maiti B, et al. The E2F1-3 transcription factors are essential for cellular proliferation. Nature 2001; 414:457-62.

DeGregori J. The genetics of the E2F family of transcription factors: shared functions and unique roles. Biochim. Biophys. Acta. 2002; 1602:131-50.

E2F transcription factor 3, E2F-3

ELISA, WB, IHC-P, IF

4503433

Liquid