E2F6 Antilichaam - middengebied: Biotine (ARP3221_T100-Biotine)

E2F transcription factor 6

E2F-6

1876

Q6Q9Z5

NP_997705

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig

The immunogen is a synthetic peptide directed towards the middle region of human E2F6

E2F6 is a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants encoding several different isoforms have been found for this gene.

TFDP2; TFDP1; KRTAP10-7; LYN; ARAF; APP; PCGF6; RYBP; YAF2; RNF2; SMARCAD1; UBC; L3MBTL2; EZH2; Epc1; EED; KMT2D; KMT2A; RING1; E2F1; BMI1; ZMYND8; ZMYND11; KDM5C; EZH1; CBX3; E2F6

Biotin

Polyclonal Antibody

IHC, WB

E2F6 is supported by BioGPS gene expression data to be expressed in HepG2

0.5 mg/ml

Cow: 92%; Dog: 100%; Guinea Pig: 85%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

14kDa

Kimura, K., et al., (2006) Genome Res. 16 (1), 55-65

Wet Ice

129

E2F6

E2F6

Rabbit

E2F6 splice variant f EMBL AAT02641.1

NM_212540

HEQIVIAVKAPAETRLDVPAPREDSITVHIRSTNGPIDVYLCEVEQGQTS