EAP30 Polyklonale Antilichaam, Cy5 Vervoeging

Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.

Dot3; ELL associated protein of 30 kDa; ELL-associated protein of 30 kDa; ESCRT-II complex subunit VPS22; hVps22; snf8; SNF8 ESCRTII complex subunit homolog (S cerevisiae) ; SNF8_HUMAN; Vacuolar sorting protein SNF8; Vacuolar-sorting protein SNF8; VPS22.

11267

Q96H20

Cytoplasm

Rat

31-130/258

EAP30

Cy5

KLH conjugated synthetic peptide derived from human EAP30

IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

625,650nm/670nm

1µg/µl

IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

11267

Human, Mouse, Cow, Sheep, Pig, Horse, Chicken, Rabbit