ECRG4 Antilichaam

ECRG4 Antibody: The esophageal cancer-related gene 4 (ECRG4), also known as Augurin, was identified through differential display screening between esophageal cancer and normal tissue. Hypermethylation of CpG sites in the ECRG4 promoter correlate with ECRG4 downregulation in numerous esophageal squamous cell carcinoma tissues.. In transfected cells, overexpression of ECRG4 induced G1 arrest, dephosphorylation of Rb and decreased expression of cyclins D1 and D3. Increased expression of ECRG4 in aged mouse brain is observed compared with young mouse brain. The increased ECRG4 level was accompanied by elevated senescence-associated acidic beta-galactosidase activity, suggesting that ECRG4 is involved in cellular differentiation and senescence.

84417

Q9H1Z8

Q9H1Z8

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

ECRG4 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (75%)

ECRG4 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ECRG4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

ECRG4 antibody is predicted to not cross-react with other ECRG family members.

C2orf40

Cat. No. 17-001 - HeLa Cell Slide

Chromosome 2 open reading frame 40

Homo sapiens

Su T, Liu H, and Lu S. Cloning and identification of cDNA fragments related to human esophageal cancer. Zhonghua Zhong Liu Za Zhi 1998; 20:254-7.

Yue CM, Deng DJ, Bi MX, et al. Expression of ECRG4, a novel esophageal cancer-related gene, downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma. World J. Gastroenterol. 2003; 9:1174-8.

Kujuro Y, Suzuki N, and Kondo T. Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells. Proc. Natl. Acad. Sci. USA 2010; 107:8259-64.

ECRG4 Antibody: ECRG4, ECRG4, UNQ761/PRO1508, Augurin, Esophageal cancer-related gene 4 protein

ELISA, WB, ICC

14165276

Liquid