EDARADD Antilichaam

This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

128178

Q8WWZ3

Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human EDARADD (NP_665860.2) .

Unconjugated

Primary Antibodies

Cell Cycle, Signal Transduction

Affinity purification

Mouse pancreas

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 25kDa

IgG

WB: 1:500 - 1:2000

EDARADD

EDAR associated death domain

Homo sapiens

ECTD11A, ECTD11B, ED3, EDA3, ectodysplasin-A receptor-associated adapter protein, EDAR-associated death domain protein, crinkled homolog, ectodysplasia A receptor associated death domain

WB

Liquid