EDG8 Antilichaam - N-terminaal gebied: Biotine (ARP42662_P050-Biotine)

Sphingosine-1-phosphate receptor 5

EDG8, S1P5, Edg-8, SPPR-1, SPPR-2

53637

Q9H228

NP_110387

Human, Mouse, Rat, Cow, Dog, Pig

The immunogen is a synthetic peptide directed towards the N terminal region of human EDG8

EDG8 is a receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) . S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. It Is coupled to both the G (i/0) alpha and G (12) subclass of heteromeric G-proteins (By similarity) . It may play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.

TP63; GNA12; GNAO1; GNAI1; SGPP1

Biotin

Polyclonal Antibody

IHC, WB

Affinity Purified

0.5 mg/ml

Cow: 93%; Dog: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

44kDa

Otsuki, T., (2005) DNA Res. 12 (2), 117-126

Wet Ice

398

S1PR5

S1PR5

Rabbit

Sphingosine 1-phosphate receptor 5

NM_030760

MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFI